Development and Validation of a Liquid Chromatography Method for the Analysis of Paromomycin Sulfate and its Impurities
نویسندگان
چکیده
Paromomycin (PARO, synonym: aminosidine, Figure 1), a broad spectrum aminoglycoside antibiotic first isolated in 1956 from the fermentation of streptomyces[1], shows activity against both grampositive and gram-negative bacteria as well as some protozoa and cestodes. Although it is not used as an antibiotic any more, paromomycin has been approved since 2007 in India as an effective, well tolerated and affordable treatment for visceral leishmaniasis (VL) [2]. Recently it is being developed for use against multi-drug resistant strains of tuberculosis [3-4] and for the treatment of intestinal cryptosporidiosis in AIDS patients [5-8].
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